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Yes, it is possible to mix direct access to registers with IO class calls.

IO class is meant for convenience and cross device portability, speed is secondary consideration. It can be used to configure individual pin (if hardware allows that) at any time using IO.Configure(). IO pin set/clear is slower then direct register access because it incurs overhead of calling .Set or .Clr methods.

Example:

				
					Sub Main()
						Dim res As Boolean

						res=IO.Configure(P1_25_OUT)

						Do
						 IO1SET = &B00000010000000000000000000000000
						 IO1CLR = &B00000010000000000000000000000000
						Loop

					End Sub